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Home - Products - Endocrinology/Hormones - 5-HT Receptor - Ro 60-0175

Ro 60-0175

CAS No. 169675-08-5

Ro 60-0175 ( Ro 600175 )

Catalog No. M12587 CAS No. 169675-08-5

Ro 60-0175 is a potent, selective 5-HT2C receptor agonist.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Ro 60-0175
  • Note
    Research use only, not for human use.
  • Brief Description
    Ro 60-0175 is a potent, selective 5-HT2C receptor agonist.
  • Description
    Ro 60-0175 is a potent, selective 5-HT2C receptor agonist with pKi of 9, 7.5, 5.4, 5.2 and 5.6 for human 5-HT2C, 2A, 1A, 6 and 7 receptors respectively; induces hypolocomotion in rats at doses greater than 0.5 mg/kg s.c.; (0.3 and 1 mg/kg s.c.) simultaneously reduces both unpunished and punished lever pressing, a profile consistent with sedation, induces sedative-like responses via 5-HT(2C) receptor activation in vivo.
  • Synonyms
    Ro 600175
  • Pathway
    Endocrinology/Hormones
  • Target
    5-HT Receptor
  • Recptor
    5-HT Receptor
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    169675-08-5
  • Formula Weight
    226.68
  • Molecular Formula
    C11H12ClFN2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    CC(CN1C=CC2=CC(=C(C=C21)Cl)F)N.C(=CC(=O)O)C(=O)O
  • Chemical Name
    1H-Indole-1-ethanamine, 6-chloro-5-fluoro-α-methyl-, (S)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Damjanoska KJ, et al. J Pharmacol Exp Ther. 2003 Mar;304(3):1209-16.
2. Vickers SP, et al. Br J Pharmacol. 2000 Jul;130(6):1305-14.
3. Kennett G, et al. Eur J Pharmacol. 2000 Jan 10;387(2):197-204.
4. Jenck F, et al. Eur Neuropsychopharmacol. 1998 Aug;8(3):161-8.
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